Tylenol's Impact on Glutathione and Liver Damage Why you should avoid REGULAR acetaminophen use for babies and pregnancy 3 Little Plums Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which Figure 1 from Acetaminophen toxicity and 5 oxoproline (pyroglutamic acid): a tale of two cycles, one an ATP depleting futile cycle and the other a useful cycle. Semantic Scholar Acetaminophen metabolism Acetaminophen Anesthesia Key