Could Tylenol be making your child's health worse? Acetaminophen is widely used for pain and fever relief, but research suggests it depletes glutathione, a powerful antioxidant essential for immune function, Data summary: IL 4 regulates glutathione levels in the liver and lung Download Scientific Diagram As a naturopathic doctor and a mom, Tylenol is a hard no in my house and I want to explain why. , , Acetaminophen (Tylenol) is processed through the liver, and in that process it can lower Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Sex differences in glutathione metabolism and acetaminophen toxicity Frontiers Herbal Therapy for the Treatment of Acetaminophen Associated Liver Injury: Recent Advances and Future Perspectives