The Super Antioxidants: Glutathione And NAC! OC Integrative Medicine Acetaminophen detoxification in cucumber plants via induction of glutathione S transferases ScienceDirect A Possible Antidote for Tylenol (Paracetamol) Overdose American Council on Science and Health Here's how to make Tylenol work way better Dose it correctly: 1,000 mg at a time, spaced every 8 hours. Smaller doses don't control pain as well. Take it Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. The Metabolism of Acetaminophen and the Synthesis of Glutathione Download Scientific Diagram