Acetaminophen Toxicity and Management (SliExam3) Flashcards Quizlet GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Simplified scheme of APAP metabolism, leading to the formation of NAPQI Download Scientific Diagram What Are the Potential Sites of Protein Arylation by N Acetyl p benzoquinone Imine (NAPQI)? Chemical Research in Toxicology The Use and Potential Benefits of N Acetylcysteine in Non Acetaminophen Acute Liver Failure: An Etiology Based Review