5 Oxoprolinuria as a Cause for Metabolic Acidosis Renal Fellow Network Episode 203: Acetaminophen Toxicity Core EM The Hidden Impact of Acetaminophen Well Rooted Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg kg intravenous acetaminophen in very preterm infants Pediatric Research Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen Pathway (toxic doses), Pharmacokinetics