Interaction with Ethanol Alcohol Metabolism Problem 2: N acetyl para benzoquinone (NAPQI) is an oxidized metabolite of acetaminophen formed in the liver. NAPQI is converted into an acetaminophen glutathione conjugate, a non toxic metabolite Metabolic pathway for NAPQI formation and detoxification by conjugation Download Scientific Diagram Site of Reactivity Models Predict Molecular Reactivity of Diverse Chemicals with Glutathione Chemical Research in Toxicology Did you know that high doses of paracetamol can be toxic to your liver? Paracetamol, also known as acetaminophen, is a commonly used painkiller that can have harmful effects on the body Liver injury induced by paracetamol and challenges associated with intentional and unintentional use